Profenum
Application: intramuscularly, intravenously
Indications: Preparation is applied to cattle, pigs, horses, dogs and cats as anti-inflammatory, analgesic and antipyretic agent in complex therapy in obstetric-gynaecological (mastitis, endometritis, mastitis-metrite-agalactia syndrome), gastrointestinal (colic), respiratory pathologies (pneumonia, bronchitis, etc.)as well as acute and chronic diseases of the musculoskeletal system, accompanied by pain and inflammation (postoperative pains, fractures, traumatic arthropathies, sprained ligaments and tendons, osteoarthritis, chronic degenerative joint diseases, etc.) and to eliminate pain syndrome of various etiologies.
Pharmacological properties
Profen belongs to the group of non-steroidal anti-inflammatory drugs.
Ketoprofen, which is part of the preparation, is a derivative of propionic acid, has a pronounced antiflammatory, analgesic and antipyretic effect, suppresses platelet aggregation. The mechanism of action of ketoprofen is based on the suppression of the synthesis of prostaglandins as a result of exposure to cyclooxygenase and lipooxygenase metabolism of arachidonic acid, stabilizes lysosomal membranes, and causes inhibition of neutrophil activity in animals with arthritis.
Ketoprofen is rapidly absorbed from the injection site, enters the blood and most organs and tissues, reaching a maximum concentration in blood plasma after 30-40 minutes, is excreted from the body mainly with urine.
In the recommended doses, it does not have a locally irritating, sensitizing and embryotoxic effect, does not cumulate in the body.
Doses and mode of use
cattle: 1 ml per 30 kg of animal body weight intramuscularly or intravenously once a day for 1-3 days;
pigs: 1 ml per 30 kg body weight of the animal intramuscularly once a day for 1-3 days;
horses: 1 ml per 45 kg of animal body weight intravenously, with the treatment of the musculoskeletal system - daily 1 time/day from 3 days to 5 days; with symptomatic treatment of colic - once;
dogs and cats: 0.1 ml per 5 kg of animal body weight subcutaneously or intramuscularly once a day for 1-5 days.
Contraindications
Use of the preparation is contraindicated to animals with individual hypersensitivity to ketoprofen, gastric ulcer and 12-pectoral ulcer, hemorrhagic syndrome, pronounced hepatic and renal insufficiency, in pregnancy.
Do not use for productive horses whose meat is intended for consumption by people.
Product usage restrictions:
Slaughter of cattle for meat is allowed no earlier than 5 days, pigs - no earlier than 4 days after the last use of the drug. In the case of forced slaughter of animals, meat is used to feed carnivores before the prescribed period. Milk during and after the use of the preparation can be used without limitation.
Terms and conditions of storage:
The preparation is stored in the manufacturer's package according to list B in a place protected from light at a temperature of plus 5 ° C to plus 25 ° C. The drug is stored separately from food and feed, in a place inaccessible to children.
Primary packaging:
The preparation is released in glass vials of 10 ml, 20 ml, 50 ml and 100 ml.